Endocrinology & Diabetes

Hormonal Regulation of Metabolism

Hormonal regulation of metabolism involves a complex interplay of hormones that control energy balance, glucose homeostasis, and fat storage. Insulin, produced by the pancreas, facilitates glucose uptake into cells and promotes glycogen and fat storage, lowering blood sugar levels. Glucagon, also from the pancreas, raises blood glucose by stimulating glycogen breakdown and glucose release. Thyroid hormones (T3 and T4) regulate overall metabolic rate and influence energy expenditure. Cortisol, produced by the adrenal glands, impacts glucose metabolism and stress response, affecting fat and protein metabolism. Leptin and ghrelin, hormones from adipose tissue and the stomach respectively, regulate appetite and energy balance. Disruptions in these hormonal signals can lead to metabolic disorders such as diabetes, obesity, and thyroid diseases. Understanding these hormonal interactions is crucial for managing and treating metabolic conditions effectively.